lungcancer, postoperative pain
Conditions
Interventions
Patients will be randomized (1:1) to receive either pain treatment with ESP (the study group) or TEA (the control group). Patients in the intervention group receive continuous ESP analgesia (ESP) with
Sponsors
Catharina ziekenhuis Eindhoven
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: (1) Age between 18 and 75 years old, (2) BMI between 20 and 30kg/m 2 , (3) scheduled for elective VATS, and (4) written informed consent.
Exclusion criteria
Exclusion criteria: Exclusion criteria are as follows: (1) ASA status = 4, (2) chronic opioid use (> 3 months of strong opioids, weak opioids such as tramadol are allowed), (3) renal or liver failure inhibiting the systematic use of paracetamol and/or NSAIDs, (4) contraindication for epidural analgesia (e.g. INR or platelets according to local protocol, local infection at the surgery site or puncture site) (5) allergy to study medication, (6) pregnancy, (7) cognitive impairment, (8) insufficient comprehension of the Dutch QoR-40 questionnaire.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of this study is the QoR15 (See section 6.1.) on POD1 and 2 including subscale analysis Comfort; Emotions, Independence, Support and Pain). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints include - postoperative Visual Analog Scales (VAS) score on day 1 and 2 (assessed at rest and when moving (coughing) in the morning and in the evening) - Length of hospital stay (LOS), - requirement of rescue medication - postoperative morphine-equivalent consumption per day, - failure of analgesic technique (defined as catheter failure, need for specialist intervention and/ or need for rescue medication) (Table 1) - the total operative time (recorded as total time spent in the operating room, anesthetic time, surgical time), - complications related to surgery (e.g. bleeding, surgical site infection, conversion to open procedure), - complications related to pain treatment (e.g. epidural hematoma and abscess or local anesthetic toxicity) - duration of bladder catheterization, - first mobilization to chair and > 20 meters - 30 days post-surgical evaluation by phone of pain, opioid use and patient satisfaction | — |
Contacts
Public ContactR.A. Bouwman
Outcome results
None listed