The Ehlers-Danlos syndrome, locoregional anesthesia. Het Ehlers-Danlos syndroom, cutis hyperelastica, locoregionale anesthesie
Conditions
Interventions
Sponsors
sponsor: A.J.M. van Wijck, MD PhD, department of anesthesiology, UMC Utrecht
principal investigator: J.C. Mier, MD, department of anesthesiology, UMC Utrecht
Eligibility
Inclusion criteria
Inclusion criteria: For the Ehlers-Danlos group: 1. people with all types of Ehlers-Danlos except type IV, proven by a geneticist or a comparably qualified person; 2. 18 to 65 years old; 3. informed consent. For the control group: All subjects are matched with a patient from the Ehlers-Danlos group for age and sexe.
Exclusion criteria
Exclusion criteria: For Ehlers-Danlos patients: 1. Type IV Ehlers-Danlos; 2. co-existing disease which increases the risk of locoregional anesthesia, according to prudent daily clinical practice; 3. hereditary acquired or drug induced bleeding disorders; 4. periferal mononeuropathy, polyneuropathy, multiple sclerosis or other relevant neurologic disorder.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Analgesia in the region of the ulnar nerve within 60 minutes after application of an ulnar nerve block.This will be demonstrated by increasing stimuli from a neurostimulator. If the subject does not regard 20 mA as painful there is of an adequate block. | — |
Secondary
| Measure | Time frame |
|---|---|
| Analgesia from the subcutanous injections and the topical application of EMLA cream. Time of onset of analgesia. Time of end of analgesia. Duration of analgesia. | — |
Contacts
Public ContactJ.C. Mier
University Medical Center Utrecht (UMCU), P.O. Box 85500, Heidelberglaan 100
Outcome results
None listed