(non-infectious) ocular inflammation, uveitis, age related macular degeneration, inflammatory corneal disease, idiopathic inflammatory orbital disease
Conditions
Interventions
Sponsors
University Medical Centre Utrecht
Eligibility
Inclusion criteria
Inclusion criteria: - 18-95 years of age - diagnosed with non-infectious uveitis (anterior, intermediate, posterior, panuveitis, scleritis) OR - inflammatory corneal disease (keratokonus, Fuchs endothelial corneal dystrophy) OR - idiopathic inflammatory orbital disease OR - age-related macular degeneration
Exclusion criteria
Exclusion criteria: - (acquired) immune deficiencies - inadequate knowledge of Dutch - current use of systemic immunomodulatory agents, biologicals or cyclosporine - IV corticosteroids in last 14 days before inclusion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We aim to employ an "omics"-driven systems biology approach on patients with ocular inflammation in order to identify the molecular pathways underlying the pathogenesis of ocular and orbital inflammation and develop clinically usefull markers to predict disease outcome and treatment responses (eg biomarkers). For this we study multiple layers of the immune system (genome, epigenome, proteome, metabolome and cellsubsets). | — |
Secondary
| Measure | Time frame |
|---|---|
| To identify new therapeutical targets for potential use in future clinical studies by evaluation of novel biomarkers in functional models | — |
Contacts
Public ContactJonas Kuiper
Department of Ophthalmology University Medical Centre Utrecht
Outcome results
None listed