kidney transplantation circadian rhythm sleep disturbances ambulatory blood pressure Dutch: niertransplantatie, circadiane ritmiek, slaapstoornissen, 24u-bloeddruk
Conditions
Interventions
The course of the circadian rhythms of melatonin, ambulatory blood pressure, body temperature and sleep are measured in kidney transplant recipients and their living kidney donors before and after kid
Sponsors
VU University Medical Centre, Amsterdam, The Netherlands
Meander Medical Centre, Amersfoort, The Netherlands
Eligibility
Inclusion criteria
Inclusion criteria: Kidney recipients: 1. Aged 18-85 yr, both male and female; 2. Living donor transplantation; 3. Good understanding of dutch language; 4. Informed consent. Kidney donors: 1. Aged 18-85 yr, both male and female; 2. Good understanding of dutch language; 3. Informed consent.
Exclusion criteria
Exclusion criteria: Both recipients and donors: 1. Use of hypnotics/melatonin during study measurements; 2. Relevant co-morbidity that interferes with participation in the study according to the investigators (e.g. heart failure NYHA class IV, instable AP, pulmonary, psychiatric, neurologic, blindness); 3. Documented sleep apnea; 4. Alcohol / drug abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recurrence of the 'dim light melatonin onset' (DLMO) after kidney transplantation in kidney transplant recipients. Definition of the DLMO: melatonin concentration peak >4 pg/ml saliva, between 7 and 12 pm. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Change in subjective and objective sleep parameters; 2. Circadian body temperature; 3. Ambulant blood pressure profile; 4. Quality of life. | — |
Contacts
Public ContactM. Russcher
Meander Medical Centre dept. Hospital Pharmacy PO Box 1502
Outcome results
None listed