totale knie vervanging, total knee replacement, osteoartrose, osteoarthritis, lokale pijnstilling, local analgesia
Conditions
Interventions
Patients will be treated with three single local analgesia shots with ropivacaine during the operation. After the operation, blood samples en shed blood will be analysed on total and free ropivacaine
Sponsors
MC Haaglanden
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients planned for primary TKR who are clinically able to undergo such a procedure; 2. Patients must have pre-operative haemoglobin levels above 7.5 mmol/L; 3. Patients will be operated under spinal anaesthesia; 4. Male and non-pregnant female patients between 18-90 years of age; 5. Patients with BMI <40; 6. Patients are able to have a venous cannula in both arms; 7. Patients with moderate renal function (MDRD 30-50mL/min).
Exclusion criteria
Exclusion criteria: 1. Patients with a major surgical procedure during the 12 weeks before the study-related operation; 2. Patients with documented allergy for the medication (ropivacaine, bupivacaine, NSAIDs, aminoacetophen or opiates) used in the study or any other local anaesthetic of the amino amide type; 3. Recent Myocardial Infarction or CVA (<3 months); 4. Patients with elevated risk of epileptic seizures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Ropivacaine levels in the shed blood collected with Bellovac ABT; 2. Ropivacaine levels in the circulating blood of the patient. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. VAS pain scores per hospital protocol; 2. Opioid consumption (amount of morphine used with PCA pump) 24, 48 and 72hrs; 3. Several important time points will be documented: Start operation, injection of single shot, tourniquet release, leaving recovery and blood samples; 4. Muscle power according to MRC. | — |
Contacts
Public ContactB.J.W. Thomassen
Haaglanden Medical Center PO Box 432
Outcome results
None listed