subarachnoid hemorrhage intracerebral hemorrhage subarachnoidale bloeding hersenbloeding
Conditions
Interventions
TXA group:
Standard treatment with additional administration of 1 g TXA intravenously in ten minutes, immediately after the diagnosis SAH, succeeded by continuous infusion of 1 g per 8 hours until a
Sponsors
Academic Medical Center
Meibergdreef 9
1105 AZ Amsterdam
Tel: 020-5666564
Fax: 020-5669590
Eligibility
Inclusion criteria
Inclusion criteria: 1. Admission to one of the study centers or their referring hospitals; 2. CT-confirmed SAH with ictus less than 24 hours ago; 3. Age 18 years and older; 4. Informed consent.
Exclusion criteria
Exclusion criteria: 1. No loss of consciousness after the hemorrhage with WFNS grade 1 or 2 on admission in combination with a perimesencephalic hemorrhage; 2. Bleeding pattern on CT compatible with a traumatic SAH; 3. Treatment for deep vein thrombosis; 4. History of blood coagulation disorder; 5. Pregnancy or breastfeeding; 6. Severe renal (serum creatinin >150 mmol/L) or liver failure (AST > 150 U/l or ALT > 150 U/l or AF > 150 U/l or ã-GT > 150 U/l); 7. Imminent death within 24 hours.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Modified Rankin Scale score dichotomized as a favourable (0-3) or unfavourable (4-6) outcome. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Case fatality rate; 2. Cause of poor outcome; 3. Rebleed rate; 4. Thromboembolic complications; 5. Delayed cerebral ischemia rate; 6. Complications (hydrocephalus, thromboembolic events, extracranial thrombosis or hemorrhagic complications); 7. Care costs. | — |
Contacts
Public ContactD. Verbaan
AMC Meibergdreef 9
Outcome results
None listed