Major abdominal surgery
Conditions
Interventions
Propofol administration at different plasma concentrations.
Sponsors
afdeling anesthesiologie van het LUMC
Eligibility
Inclusion criteria
Inclusion criteria: Adult patients requiring mechanical ventilation after elective esophagus resection or Whipple surgery admitted to the post-anaesthesia care unit (PACU) with an indication for pulmonary artery catheter monitoring.
Exclusion criteria
Exclusion criteria: 1. Hemodynamic instability with a mean arterial pressure (MAP) 18 mm Hg and/ or a cardiac index < 2.0 L•min-1 or dependence on high dosages of inotropic drugs after admittance to the PACU; 2. Severe arrhythmias; 3. Intra-cardiac shunts; 4. Prior diagnosis of aberrant cardiovascular anatomy; 5. Symptomatic peripheral vascular disease; 6. Symptomatic pulmonary disease; 7. Clinically significant aortic aneurysm; 8. Significant valvular regurgitation.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Mean systemic filling pressure, MAP, Pv, CVP, PAP, HR, SVV and PPV. | — |
Primary
| Measure | Time frame |
|---|---|
| Cardiac output values (thermodilution, LidCO, Vigileo, Hemosonic). | — |
Contacts
Public ContactBart Geerts
LUMC, P5Q-32
Outcome results
None listed