Insulin resistance, diabetes, obesity and inflammation
Conditions
Interventions
Based on the eucaloric diet in the run-in phase, a hypercaloric diet will be designed calculated as 1.4 x kcal in the eucaloric diet. The protein, fat and carbohydrate content of the diet will respect
Sponsors
Department of Endocrinology and Metabolism
Academic Medical Center, Amsterdam, the Netherlands
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age between 30-50 2. normal glucose tolerance (OGTT) 3. Caucasian men 4. normal weight BMI >20 and <25
Exclusion criteria
Exclusion criteria: 1. Age 50 years 2. Frequent intensive exercise (>2 week) or sedentary life style 3. Any medication 4. Lipid disorders, renal insufficiency, elevated liver enzymes 5. Obesity in the past 6. BMI 25 kg/m2 7. Smoking 8. Unstable weight 3 months prior to study inclusion 9. High blood pressure 10. Alcohol abuse (> 3day) 11. Participation in research during the year prior to inclusion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Weight gain and loss - Pro-inflammatory response in adipose tissue and in plasma after initialising a hypercaloric diet - Change in inflammatory response after switching to hypocaloric diet - Insulin sensitivity; Homa-IR and B-cell function - Changes in incretine response in relation to hyper- and hypocaloric diet | — |
Secondary
| Measure | Time frame |
|---|---|
| - Changes in symphatic nervous activity - Glucoregulatory hormones | — |
Contacts
Public ContactM. Brands
Academic Medical Center (AMC) F5-162 Endocrinology and Metabolism
Outcome results
None listed