aristocaths, catheter infections, catheter infecties, Ethanol lock solution, paediatric oncology patients
Conditions
Interventions
Central randomisation will be performed, allocating the patients to the control or experimental group. Both the patient and the investigators will be blinded tot the treatment.
The experimental grou
Sponsors
Academic Medical Center, Amsterdam
Eligibility
Inclusion criteria
Inclusion criteria: Paediatric oncology patients between 1 and 18 years of age with a newly inserted tunnelled central venous catheter (both internal and external devices) will be eligible for the study.
Exclusion criteria
Exclusion criteria: 1. Children who have a documented infection at the time of catheter insertion 2. Children <1 year at diagnosis 3. Children with an existing primary immunological disorder 4. Placement of the central venous catheter in the site of a previously radiographically confirmed venous thrombosis 5. Allergy for ethanol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| First endpoint: All patients will be prospectively followed till time of first documented catheter related infection, till death, or till removal of the catheter, whatever endpoint will come first. Maximum duration of the study 6 months. Secondary endpoint: Occurence of fever (with or without neutropenia), occurence of thrombosis (clinical or subclinical days of hospital admission, clinical sverity of the infection, outcome. | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects will be registered, focussing on allergic reactions, “flushing” of the face, dizziness, warm feeling and liver (ASAT, ALAT) These reactions will be registered in the first hour after flushing the lock. | — |
Contacts
Public ContactK.M. Pal, van der-de Bruin
TNO Quality of Life, P.O. Box 2215
Outcome results
None listed