Heart Failure, Pulmonary hypertension, right-heart catheterization, echocardiography, MRI, hartfalen, pulmonale hypertensie, rechts kathterisatie, echocardiografie
Conditions
Interventions
None listed
Sponsors
MUMC+
Eligibility
Inclusion criteria
Inclusion criteria: 1. Adult patients (i.e. >18 years of age) 2. Receiving right-heart catheterization for a clinical indication
Exclusion criteria
Exclusion criteria: 1. Contra-indication for MRI or unable to undergo MRI protocol due to physical condition - Current atrial fibrillation/atrial flutter - Current premature ventricular contractions (PVCs) exceeding 10% of total number of heartbeats, e.g. a heart rate of 60/min and >6 PVCs - BMI > 40.0 kg/m2 or body habitus not suited for undergoing MRI - Claustrophobic patients - Implanted device (i.e. pacemaker, loop recorder, implantable cardiac defibrillator, neurostimulator) - Magnetic metals in the body that do not allow MRI 2. Participation in ongoing trials for therapeutic interventions including randomized controlled trials and clinical trials of investigational medicinal products
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Our primary endpoint will be the differences and the correlation between pressures in mmHg measured during right heart catheterization, and MRI measurements of venous congestion parameters (flow pattern and dimension changes of vena cava superior). | — |
Secondary
| Measure | Time frame |
|---|---|
| i. The differences and the correlation between pressures in mmHg, measured during right heart catheterization and echocardiographic measurements of CVP (vena cava inferior). Additionally, echocardiographic measurement of vena jugularis interna flow will be included. ii. The differences and the correlation between measurements of echocardiography and MRI. iii. Correlation between NT-proBNP and right-sided intra-cardiac pressures | — |
Contacts
Public ContactNGHM Marcks
Outcome results
None listed