Chronic heart failure, High intensity training, Skeletal muscle metabolism
Conditions
Interventions
HIT is performed 3 times a week during 12 weeks and consists of 4 intervals of 4 minutes cycling on a ergometer at 85-95% of the peak aerobic capacity (peak Vo2) separated by 3 minute active pauses at
Sponsors
Maxima Medisch Centrum Veldhoven
Eligibility
Inclusion criteria
Inclusion criteria: 1. Written informed consent; 2. Stable systolic heart failure secondary to ischemic or dilated cardiomyopathy New York Heart Association (NYHA) class II or III (without change in class or medication < 3 months prior to inclusion); 3. Left ventricular ejection fraction of ≤ 40% (assessed within 3 months before inclusion by echocardiography, MRI or radionuclear measurement).
Exclusion criteria
Exclusion criteria: 1. Pacemaker / implantable cardioverter defibrillator (ICD) or other contra indication for magnetic resonance imaging; 2. Claustrophobia; 3. Myocardial infarction or unstable angina less than 3 months prior to inclusion; 4. Clinical signs of decompensated heart failure; 5. Ventricular tachycardia or ischemia during exercise 6. Participation in a training program (> 2/week) in the last year; 7. Intracardiac shunts or congenital heart disease limiting exercise capacity; 8. Orthopaedic, vascular, pulmonary, neuromuscular and other disease limiting exercise capacity.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in skeletal muscle metabolic recovery after submaximal exercise (leg extension in the supine position) assessed by 31P MR spectroscopy measurements in M. vastus lateralis after 3 months of physical training (rate of post-exercise phosphocreatine increase, expressed as tau-PCr). Changes in skeletal muscle re-oxygenation assessed simultaneously at the same location by Near Infrared Spectroscopy (rate of post-exercise decrease in deoxygenated hemoglobin, expressed as MRT-HHb). | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in maximal exercise capacity (by changes in peak Vo2), left ventricular function (left ventricular ejection fraction and end systolic volume) and Quality of life (Minnesota living with heart failure questionnaire) after 3 months of physical training. | — |
Contacts
Public ContactV. Niemeijer
Postbus 7777
Outcome results
None listed