Periodontitis - Parodontitis Vitamin C - Vitamine C Flavanoids - Flavonoiden Quercetin - Quercetine
Conditions
Interventions
The intervention will be the intake of daily food supplements in the two test groups as compared to the intake of non-active supplements in the control group.
Sponsors
Academic Centre for Dentistry Amsterdam (ACTA)
University of Amsterdam (UVA) and Vrije Universiteit (VU) Amsterdam
Gustav Mahlerlaan 3004, 1081 LA Amsterdam
The Netherlands
Eligibility
Inclusion criteria
Inclusion criteria: - age: ≥18 years; - proximal bone loss of ≥ 3mm in 2 non-adjacent teeth; - probing pocket depth ≥ 3 mm and bleeding on probing on at least 25% of their total sites and documented radiographic bone loss; - good general health.
Exclusion criteria
Exclusion criteria: - diagnosis of any acute periodontal problem which requires immediate treatment; - use of antibiotics within the previous 6 months; - pregnant or lactating women; - previous initial periodontal treatment within the last year; - current orthodontic treatment; - use of any medication which may interfere with quercetin, or with the study outcomes. - current daily use of supplements containing vitamin C
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary response variable of the present study with respect to the clinical measurements is bleeding on pocket probing (bop). | — |
Secondary
| Measure | Time frame |
|---|---|
| With regard to the systemic inflammatory biomarkers HbA1C, hs-CRP, and vitamin C (from venous blood). | — |
Contacts
Public ContactW. J. Teeuw
Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam (UvA) and Vrije Universiteit (VU) Amsterdam
Outcome results
None listed