Assessment of a novel strategy to attenuate muscle mass loss during 2 weeks of bed rest

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON22281

Enrollment

Registered

2017-04-14

Start date

2017-07-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Disuse, Immobilization, Injury

Interventions

The main intervention: the amount of muscle mass that is lost following 2 weeks of bed rest will be assessed and whether BFR can be applied to effectively preserve muscle mass and strength during bed

Eligibility

Inclusion criteria

Inclusion criteria: • Healthy males • Age between 18 and 35 y • BMI between 18.5 and 30 kg/m2

Exclusion criteria

Exclusion criteria: • Smoking • Type 2 Diabetes Mellitus • Any back/leg/knee/neck/postural complaints   • Any history and/or family history of thrombosis   • All co-morbidities interacting with mobility and muscle metabolism of the lower limbs  (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis) • Myocardial infarction within the last 3 years • Use of certain anti-coagulants (use of thrombocyte aggregation inhibitors such as Ascal,  acetylsalicylic acid, aspirin and carbasalaatcalcium is permitted. Use of other thrombocyte aggregation inhibitors will be discussed with the responsible physician)   • Performing regular resistance training (3+ times per week, carrying out progressive training) in the previous 6 months • Hypertension (according to WHO criteria) and/or cardiovascular disease • A history of deep vein thrombosis (DVT) in the leg • Having donated blood in the 3 months prior to the study

Design outcomes

Primary

Measure	Time frame
To assess the amount of muscle mass that is lost following 2 weeks of bed rest and whether BFR can be applied to effectively preserve muscle mass and strength during bed rest.	—

Secondary

Measure	Time frame
To assess differences in muscle fiber cross-sectional area (CSA), satellite cell content/activation, muscle fiber vascularization, muscle protein synthesis rates between both legs (BFR vs control), muscle strength, whole-body fat mass, adipose tissue gene expression and oral glucose tolerance before and after 2 weeks of bed rest.	—

Contacts

Public ContactCas Fuchs

Maastricht University, Dep. Human Biology

cas.fuchs@maastrichtuniversity.nl0433881381

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)