Necrotising enterocolitis Near Infrared Spectroscopy (NIRS) Faecal microbiota Biomarkers Gut wall integrity Bile acids
Conditions
Interventions
none
Sponsors
University Medical Center Groningen
Eligibility
Inclusion criteria
Inclusion criteria: All children admitted to the neonatology department, which are - born at a gestational age of <30 weeks or - born with a birth weight of <1000 gram or - born at a gestational age of <32 weeks and categorized as small for gestational age (birth-weight ¡Ü 1200 gram) or - born with a cardiovascular disease resulting in a possibly reduced splanchnic bloodflow (e.g. aortic coarcation, heart disease with ductal dependent systemic circulation) or - antenatal exposed to NSAIDs (after maternal tocolysis with Indomethacine)
Exclusion criteria
Exclusion criteria: Other abdominal diseases, e.g. abdominal wall defects or congenital intestinal atresias
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Urinary i-FABP/creatinin ratio, urinary 8-OHdG/creatinine ratio, urinary F2-IsoP/creatinin ratio, faecal Calprotectin and faecal bile acids, gene-expression (ao.TLR-4) on shedded enterocytes in the faeces, GLP1/2 in plasma, bile-acids in plasma, and regional tissue oxygenation measured by abdominal/cerebral NIRS. | — |
Primary
| Measure | Time frame |
|---|---|
| The development of necrotising enterocolitis as determined by an independent paediatric radiologist (pneumatosis intestinalis on abdominal x-ray) or by surgeon during surgery | — |
Contacts
Public ContactJBF Hulscher
Hanzeplein 1
Outcome results
None listed