total knee arthroplasty, retransfusion, local anesthesia
Conditions
Interventions
Administration of local anaesthetic (single shot and continuous infusion) in TKR. Blood and tissue fluid will be collected in a Bellovac ABT system and by venous sampling and used for quantification o
Sponsors
Medical Center Haaglanden, the Hague
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients must have pre-operative haemoglobin levels above 7.5 mmol/L; 2. Patients will be operated under spinal anaesthesia; 3. Male and non-pregnant female patients between 18-90 years of age; 4. Patients with BMI <40; 5. Patients are able to have a venous cannula in both arms; 6. Patients have normal renal function for their age (MDRD); 7. ASA classification score I-II.
Exclusion criteria
Exclusion criteria: 1. Patients with a major surgical procedure during the 12 weeks before the study-related operation; 2. Patients with documented allergy for the medication (ropivacaine, bupivacaine, NSAIDs, aminoacetophen or opiates) used in the study or any other local anaesthetic of the amino amide type; 3. Recent Myocardial Infarction or CVA (<3 months); 4. Patients with elevated risk of epileptic seizures; 5. Dutch language not mastered.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ropivacaine will be quantified in patient serum (0, 3, 6 and 24 h after surgery) and in the blood-tissue fluid collected and filtered in the Bellovac ABT system in order to be able to calculate systemic exposure after reinfusion of the blood. | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS painscores. | — |
Contacts
Public ContactB.J.W. Thomassen
Haaglanden Medical Center PO Box 432
Outcome results
None listed