Protection of the heart during bypass surgery by a blood pressure cuff on the arm.

A clincical study to investigate the effects of remote ischemic preconditioning on cardiac mitochondrial hexokinase in coronary artery bypass graft patients.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON22235

Enrollment

Registered

2011-05-25

Start date

2012-02-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Bypass Grafting (CABG), Cardioprotection, Remote preconditioning

Interventions

Remote ischemic preconditioning: Will be induced by an automated cuff deflator placed on the left arm and inflated to 200 mmHg for 5 min 3 times, with subsequent reperfusion during which the cuff is d

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age > 18 years; 2. First time elective on-pump CABG surgery without valve surgery; 3. Signed written informed consent.

Exclusion criteria

Exclusion criteria: 1. Emergency operation; 2. Women; 3. Severe COPD; 4. SaO2 < 90% at room temperature; 5. Presumed non cooperatives; 6. Ejection fraction < 40%; 7. Diabetes or representing with hyperglycemia; 8. Unstable angina or angina 48h before surgery; 9. Peripheral vascular disease affecting the upper limbs; 10. Concomitant procedures; 11. Nicorandil use; 12. Increased preoperative cardiac troponin T; 13. Pre-/peri-operative morphin use; 14. Myocardial infarction within 2 weeks before surgery.

Design outcomes

Primary

Measure	Time frame
Cardioprotection measured by cardiac troponin T values and the hexokinase mitochondrial binding ratio.	—

Secondary

Measure	Time frame
Inotropic score, plasma cytokine levels (IL-6, IL-10 and TNF-alfa) and CRP.	—

Contacts

Public ContactCoert J. Zuurbier

Department Anesthesiology, M0-210 University of Amsterdam, Academic Medical Center Meibergdreef 9

+31 (0)20 5665259

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)