Eosinophilic esophagitis
Conditions
Interventions
An acid perfusion test and barostat balloon distention test will be performed at baseline. This will be repeated after 6-8 weeks of topical budesonide treatment. To investigate the relationship betwee
Sponsors
Amsterdam UMC, Location AMC
Eligibility
Inclusion criteria
Inclusion criteria: - Previous diagnosis of active EoE confirmed by histopathology e.g. presence of >15 eosinophilic granulocytes per high power field (hpf) in esophageal biopsies - Written informed consent - Age 18-75 years
Exclusion criteria
Exclusion criteria: - Any form of treatment for EoE (topical corticosteroids, PPI or dietary treatment) in the month preceding the study - ASA class III, IV or V - The need for pain medication 24 hours before the visit
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measures of sensitivity of the esophagus: 1. Perfusion sensitivity scores in histological active disease, disease in remission and healthy controls, calculated via [(total perfusion time – lag time to perception) x maximum VAS] 2. Balloon pressure that induced a sensation of discomfort in histological active disease, disease in remission and healthy controls | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Esophageal barrier function in histological active disease and disease in remission, defined as electrical tissue impedance measured with ETIS and transepithelial electrical resistance and fluorescein flux measured in Ussing chamber 2. The degree of reflux in the EoE patients, as measured with 24-hours pH- impedance measurement | — |
Contacts
Public ContactLaura Haasnoot
Amsterdam UMC, location AMC
Outcome results
None listed