Asthma
Conditions
Interventions
1. PC-strategy: aiming to achieve partly controlled asthma based on asthma control measures
2. C-strategy: aiming to achieve controlled asthma based on asthma control measures
3. FeNO-strategy: aiming to achieve controlled asthma based on asthma control measures and an indirect marker of airways inflammation.
Sponsors
-
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age 18-50 yr; 2. Doctors diagnosis of asthma; 3. A prescription of inhaled corticosteroid treatment in the last year; 4. Willing to change treatment step in order to follow the protocol; 5. Written informed consent.
Exclusion criteria
Exclusion criteria: 1. Daily or alternate day oral corticosteroid therapy within 1 month before entering the study; 2. Inability to understand written or oral Dutch instructions; 3. Active diseases likely to interfere with the purpose of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pharmaco-economics: 1. Net health benefit; 2. Cost-effectiveness; 3. Cost-utility. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Patient preferences; 2. Compliance; 3. Asthma related quality of life; 4. The number of limited activity days; 5. Exacerbations; Preplanned subgroupanalyses: 1. Smokers vs. Non-smokers; 2. Asthma control at baseline subdivided into strict, partly, or uncontrolled by Juniper Asthma Control Questionnaire scores of respectively 1.5 (Juniper et al. Resp.Med.2006); 3. Exhaled Nitric Oxide status at baseline, subdivided into low(50)); 4. Allergic vs. non-allergic Asthma; 5. BMI 30. | — |
Contacts
Public ContactP.J. Honkoop
Department of Medical Decision Making, J10-87 P.O.box 9600
Outcome results
None listed