Barrett's Esophagus Genetics Esophageal Adenocarcinoma
Conditions
Interventions
Interventions:
For all participating indivicdals (index patients and first degree relatives)
1) Barrett's Esophagus Questionnaire
2) Venipuncture
For first degree relatives that had no prior duode
Sponsors
University Medical Center Utrecht
Eligibility
Inclusion criteria
Inclusion criteria: Index patients of families that full fill one of the following diagnostic criteria for familial Barrett's esophagus or adenocarcinoma of the gastro-esophageal junction: A. Two or more first- or second degree relatives with BE or adenocarcinoma of the GEJ, with at least one diagnosed before the age of 50 B. Three or more first- or second degree relatives with BE or adenocarcinoma of the GEJ, irrespective of age C. One patient with BE or adenocarcinoma of the GEJ < 40 yrs Inclusion criteria All first degree relatives (i.e. sons, daughters, sisters, brothers and father and mother of the index patient) of the index patient
Exclusion criteria
Exclusion criteria: A potential individual who meets any of the following criteria will be excluded from participation in this study: 1) Individuals 75 years old 2) Unable to fill out questionnaire
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determine the prevalence of BE among first degree relatives of index patients of families that fulfil criteria for familial BE/adenocarcinoma of the GEJ Determine the number and type of (pre) malignant lesions in first degree relatives of index patients of families that fulfil criteria for familial BE/adenocarcinoma of the GEJ | — |
Contacts
Public ContactJ.J. Boonstra
Outcome results
None listed