Muscle mass growth
Conditions
Interventions
Exercise and quark intake
Sponsors
The collaboration project is co-funded by the PPP Allowance made available by Health~Holland, Top Sector Life Sciences & Health, to stimulate public-private partnerships. Maastricht University and Friesland campina
Eligibility
Inclusion criteria
Inclusion criteria: • Healthy males • Age between 18 and 35 y or 65 and 85 y inclusive • BMI between 18.5 and 30 kg/m2
Exclusion criteria
Exclusion criteria: • Allergies to milk proteins • Lactose intolerant • Smoking • Phenylketonuria • Diabetes Mellitus (diagnosed, or fasting glucose >7.0 mmol/L, or HbA1c >6.5) • Diagnosed GI tract disorders or diseases • Arthritic conditions • A history of neuromuscular problems • Any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications). • Use of certain anticoagulants (use of thrombocyte aggregation inhibitors such as acetylsalicylic acid and carbasalaatcalcium is permitted. Use of other thrombocyte aggregation inhibitors will be discussed with the responsible physician) • Blood donation within 2 months of study initiation • Hypertension (according to WHO criteria; >90/140 mmHg) • Recent participation in amino acid tracer studies (less than 1 year ago) • Physical activity (not training more than 3 times per week and no structured resistance training.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Muscle protein synthesis | — |
Secondary
| Measure | Time frame |
|---|---|
| whole-body protein synthesis, breakdown, oxidation, and net balance, plasma amino acids, glucose and insulin, and plasma, L-[ring-13C6]-phenylalanine, L-[ring-13C6]-tyrosine, L-[3,5-2H2]-tyrosine enrichments | — |
Contacts
Public Contactwesley Hermans
Maastricht University
Outcome results
None listed