Acute hip fracture
Conditions
Interventions
There will be two groups, an intervention group receiving a tailor-made protein-enriched diet and a control group receiving usual care.
Sponsors
Division of Human Nutrition and Health of Wageningen University & Research
Eligibility
Inclusion criteria
Inclusion criteria: ? Age = 65 years ? Acute hip fracture ? Able to give written informed consent ? Admission to a rehabilitation centre that participates in this research
Exclusion criteria
Exclusion criteria: ? Allergic, intolerant or hypersensitive to milk/lactose (self-reported) ? Not willing to stop using dietary supplements with exception of calcium and vitamin D ? Pathological fracture ? Abnormal hepatic or renal laboratory parameters, such as estimated glomerular filtration rate (eGFR) <30 ml/min/1,73 m2 (data from hospital) ? Diagnosis of disorders/diseases where a high protein intake can be harmful, such as renal impairment or failure, liver disease, or diabetes associated with nephropathy (geriatric care physician has the decisive voice). ? Diagnosis of bone metabolic disorders such as primary hyperparathyroidism, Paget’s disease, or myeloma ? Taking medication known to strongly alter bone or calcium metabolism, such as oestrogen, hormone replacement therapy, corticosteroids, anabolic agents, calcitonin, or bisphosphonates ? Disorders/diseases which may affect ability to follow study protocol and which cannot be overcome with help of a caregiver ? Current participation in other scientific research ? No permission to request information from the general practitioner/ treating specialist(s) about medical history, medication use, liver and kidney values, and details about the broken hip
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ? Markers of bone turnover: CTX and P1NP ? BMD: total hip, femoral neck, and total body ? IGF-1 levels ? Physical performance ? Muscle mass | — |
Secondary
| Measure | Time frame |
|---|---|
| ? Inpatient rehabilitation time ? Sarcopenia prevalence ? Daily life functioning ? Quality of life | — |
Contacts
Public ContactInge Groenendijk
Wageningen University and Research
Outcome results
None listed