Statin associated muscle symptoms muscle functioning (contraction efficiency, muscle relaxation, muscle fatigue) whole body aerobic fitness mitochondrial function
Conditions
Interventions
All study participants will undergo a medical screening session of 1 hour to determine whether they comply with the in- and exclusion criteria. The medical screening will contain an elaborate physical
Sponsors
Radboud University Nijmegen Medical Centre
Eligibility
Inclusion criteria
Inclusion criteria: o Age: 18-70 years old o Current statin user (group 1-2) for at least 3 months o Mentally able/ allowed to give informed consent
Exclusion criteria
Exclusion criteria: o Familial hypercholesterolemia o History of a cardiovascular event within 1 year of study participation o Impaired liver function (ALAT, ASAT, gamma-GT > 3x ULN) o Known hereditary muscle defect, creatine kinase >5 x ULN o known mitochondrial disease o Medication known to potentially interfere with muscle metabolism (fibrates, Beta blockers, laxatives, diuretics, bronchodilatators) o Impaired kidney function (creatinine 100 µmol/l) o Diabetes mellitus o Engagement in exercise for more than two hours per week
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| o Mitochondrial number (in muscle biopsy) o Blood parameters: lipid profile (total cholesterol, HDL-, LDL-cholesterol, triglycerides), liver enzymes (ASAT, ALAT, gamma-GT), creatine kinase, pyruvate and lactate o Statin concentrations in the muscle and blood o Questionnaires on muscle complaints (Short-form McGill pain questionnaire and Short-form Brief Pain Inventory) | — |
Primary
| Measure | Time frame |
|---|---|
| oEnergy generating capacity of muscle mitochondria (in muscle biopsy) oMuscle function (= muscle force, contractile speed, relaxation and fatigability) oCardiorespiratory fitness (incremental cycling test) | — |
Contacts
Public ContactSilvie Timmers
Radboud University Nijmegen Medical Centre - Department of Physiology
Outcome results
None listed