Healthy older subjects (age 65 years or older)
Conditions
Interventions
Duration of intervention: 5 weeks
Intervention group: 5 weeks
Control group: 5 weeks
Sponsors
Nutricia Research B.V.
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age 65 years or older 2. BMI from 20 through 30 kg/m2 3. Willingness and ability to comply with the protocol 4. Written informed consent 5. Be judged by the investigator to be in good health
Exclusion criteria
Exclusion criteria: 1. Any gastrointestinal (GI) disease or surgery that interferes with GI function 2. Known renal or hepatic failure 3. Known or suspected Diabetes Mellitus (fasting glucose level ¡Ý 7.0 mmol/L) 4. (History of) any cancer with the exception of basal cell carcinoma 5. Fever in the last 7 days prior to Visit 1 6. Haemoglobin in men 3 kg in last 3 months) 9. Participation to a weight loss program 10. Use of protein containing or amino acid containing nutritional supplements within one week of Visit 1
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome parameter in this study is the time to reach half incremental area under the curve (t½ iAUC) for the sum of all amino acids (total AA) comparing product A to product B. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcome parameters of this study are: • The (incremental) maximum amino acid concentration ((i)Cmax), (incremental) area under the concentration curve ((i)AUC) and t½ iAUC comparing all study products for total AA • Gastric emptying half time (t1/2), Cmax, and time until Cmax is reached (Tmax) and AUC (plasma concentrations of paracetamol) comparing all study products • Satiety questionnaire | — |
Contacts
Public ContactZandrie Hofman
Nutricia Research B.V.
Outcome results
None listed