Physical activity in early-onset dementia.

Exercise and cognition in sedentary adults with early-onset dementia (EXERCISE-ON).

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON22143

Enrollment

180

Registered

2009-11-23

Start date

2009-12-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ENG: - Early-onset dementia - Presenile dementia - Presenile Alzheimer's disease - Frontotemporal dementia - Vascular dementia - Lewy-body dementia - Physical activity - Exercise NL: - Preseniele dementie - Jong-dementerenden - Preseniele Ziekte van Alzheimer - Frontotemporaal dementie - Vasculaire dementie - Lewy-body dementie - Fysieke activiteit - Bewegen - Sport

Interventions

1. Aerobe activity program: a. Length: 3 months

b. Frequency: 3 times a week

c. Activity: primarily cycling on a cycle ergometer

d. Setting: rehabilitation centre. 2. Flexibility program: a. Length: 3 months

c. Activity: flexibility exercises and relaxation exercises

d. Setting: rehabilitation centre. 3. Aerobe activity program at home: a. Length: 3 months

c. Activity: primarily cycling

d. Setting: at home.

Eligibility

Inclusion criteria

Inclusion criteria: 1. Diagnosis of early-onset dementia (onset of complaints 15); 3. Primary caregiver available.

Exclusion criteria

Exclusion criteria: 1. Bound to a wheelchair; 2. Neurodegenerative diseases that primarily result in motor impairments, such as Parkinson's disease and Huntington's disease; 3. Cardiovascular problems, such as severe cardiac problems or servere hypertension; 4. Abuse of alcohol or other substances; 5. Trauma capitis in the medical history, in which a loss of consiousness was present of more than 15 minutes; 6. Extended history of psychiatry (major depression, bipolar disorder, psychosis); 7. Severe visual problems; 8. Severe auditive problems; 9. Insufficient mastery of the Dutch language.

Design outcomes

Primary

Measure	Time frame
1. Global cognitive functioning: Alzheimer Disease Assessment Scale (ADAS)-COG; 2. Mental speed: Trailmaking test A (TMT A); 3. Executive functioning (flexibility): Trailmaking test B (TMT B); 4. Instrumental Activities of Daily Functioning: Disability Assessment for Dementia (DAD); 5. Quality of Life: Dementia-Quality of Life (D-QOL).	—

Secondary

Measure	Time frame
1. Physical functioning: a. 6 minutes walk test; b. Sit to stand test; c. Physical Activity Scale for the Elderly (PASE). 2. Cognitive functioning: a. Mini Mental State Examination (MMSE); b. “Face recognition” and “Picture recognition” (subtest of the Rivermead Behavioural Memory Test (RBMT)); c. “Digit Span” (subtest of the Wechsler Memory Scale-Revised (WMS-R); d. Fluency: category fluency and letter fluency; e. Stroop colour word test; f. “Symbol substitution” (subtest of the Wechsler Adult Intelligence Scale – III (WAIS-III)); g. “Number location” (subtest of the Visual Object and Space Perception Battery (VOSP)); h. “Visual closure” (subtest of the Groninger Intelligence Test (GIT)). 3. Questionnaires: a. Dutch translation of the General Self-efficacy Scale; b. Centre for Epidemiologic Studies Depression; c. Rest-activty rhythm: actigraphy.	—

Measure

Time frame

1. Physical functioning: a. 6 minutes walk test; b. Sit to stand test; c. Physical Activity Scale for the Elderly (PASE). 2. Cognitive functioning: a. Mini Mental State Examination (MMSE); b. “Face recognition” and “Picture recognition” (subtest of the Rivermead Behavioural Memory Test (RBMT)); c. “Digit Span” (subtest of the Wechsler Memory Scale-Revised (WMS-R); d. Fluency: category fluency and letter fluency; e. Stroop colour word test; f. “Symbol substitution” (subtest of the Wechsler Adult Intelligence Scale – III (WAIS-III)); g. “Number location” (subtest of the Visual Object and Space Perception Battery (VOSP)); h. “Visual closure” (subtest of the Groninger Intelligence Test (GIT)). 3. Questionnaires: a. Dutch translation of the General Self-efficacy Scale; b. Centre for Epidemiologic Studies Depression; c. Rest-activty rhythm: actigraphy.

—

Contacts

Public ContactA.M. Hooghiemstra

van der Boechorstraat 1

am.hooghiemstra@psy.vu.nl+31 (0) 20 598 3999

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)