Live kidney donation, postoperative recovery, ischemia-reperfusion injury
Conditions
Interventions
Subjects in the intervention group will start a preoperative fasting regime from 60 hours before surgery. Fasting is defined as very few to no caloric intake. Subjects are free to drink unlimited wate
Sponsors
Investigator Initiated
Eligibility
Inclusion criteria
Inclusion criteria: Adult patients and donors opting for living kidney donation and transplantation at: Erasmus MC, University Medical Center in Rotterdam, The Netherlands and University Medical Center Groningen in Groningen, The Netherlands In order to be eligible to participate in this study, a subject going for live kidney donation must meet all of the following criteria: - Age between 18 and 70 years old - BMI between 19 and 35 kg/m2 - Able to provide written consent - Adequate understanding of the Dutch language
Exclusion criteria
Exclusion criteria: A potential subject (Donor) who meets any of the following criteria will be excluded from participation in this study: - Participants of the cross-over kidney donation program - Participation in another prospective trial/study for living kidney donors - HLA- or bloodtype-incompatible living kidney donation A potential subject (Recipient) who meets any of the following criteria will be excluded from participation in this study: - the use of double anticoagulants (f.i. Ascal (Carbasalate Calcium) and Clopidogrel (Plavix)). - the need for therapeutic anticoagulation with low-molecular weight heparine during admission for kidney transplantation, also known as “Bridging”.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative fatigue, scored by 36-Item Short Form Health Survey (RAND-36). The primary endpoint will be measured 4 weeks after surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| Our secondary endpoints comprise several aspects of the preoperative fasting diet, postoperative recovery and ischemia-reperfusion-injury: postoperative fatigue, admission time, adherence to the fasting diet, physical activity, renal function of the donor and recipient, upregulation of cytoprotective genes and anti-inflammatory markers, the use of uEV as a diagnostic approach and the immune-modulating effect of fasting. | — |
Contacts
Public ContactChristiaan Oudmaijer
Erasmus MC, University Medical Center Rotterdam
Outcome results
None listed