Lipbiopsie bij Sjogrens Syndrome.

Elucidating the pathogenesis of Sjögren’s syndrome: Analysis of lower lip biopsies.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON22127

Enrollment

200

Registered

2010-08-02

Start date

2010-11-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sjogrens Syndroom auto-immuun aandoeningen Xerostomie

Interventions

In all patients undergoing diagnostic lower lip biopsies, salivary gland tissue will be collected and processed using a standard protocol for formalin fixation to allow standard histological evaluatio

Eligibility

Inclusion criteria

Inclusion criteria: Patients undergoing lower lip biopsies for diagnostic purposes.

Exclusion criteria

Exclusion criteria: N/A

Design outcomes

Primary

Measure	Time frame
Obtained material will be used to elucidate primarily the B-cell pathogenesis of Sjogren's Syndrome. Using immunohistochemistry, RNS and protein analysis, the B-cel receptor (BCR), T-cell receptor (TCR), a B-cell stimulating cytokine (APRIL) and the interaction between different immune cell populations and cytokines will be studied	—

Contacts

Public ContactP.P. Tak

Academic Medical Center (AMC), Department of Clinical Immunology and Rheumatology, P.O. Box 22660

p.p.tak@amc.nl+31 (0)20 5662171

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)