English: Asthma. Atopy. Wheezing. exhaled breath analysis. Dutch: Astma. Atopie. Piepende ademhaling. Uitademingslucht analyse.
Conditions
Interventions
Sponsors
AMC Medical Center, Dept. of Respiratory Medicine, Amsterdam, The Netherlands.
Central Military Hospital, Ministery of Defence, Utrecht, The Netherlands.
Eligibility
Inclusion criteria
Inclusion criteria: 1. ≥ 17 years 2. Referred to the Central Military Hospital, dept. of Pulmonology for evaluation of asthma and/or atopy.
Exclusion criteria
Exclusion criteria: 1. < 17 years 2. Present upper respiratory infection or common cold, or in the past 2 weeks 3. Asthma exacerbation < 4 weeks 4. Present dental problems: paradontitis, recent extraction of tooth (< 2 weeks) 5. Chronic tonsillitis or sinusitis 6. Eating/drinking/smoking/brushing teeth/chewing gum/mint < 3 hours before eNose measurement 7. Use of long-acting inhaled ¦Â-agonists < 24 hours and/or use of short-acting ¦Â-agonists < 12 hours and/or use of inhaled corticosteroids < 24 hours 8. Known thyroid dysfunction and/or use of Levothyroxine 9. Known diagnosis of diabetes mellitus 10. Failure to complete eNose measurement 11. Not willing to participate in the study or lack of understanding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Electronic nose smellprint of a vital capacity volume breath sample. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Prebronchodilator spirometry according to ERS/ATS recommendations. - Histamin provocation test according to ERS/ATS recommendations. - Allergy skin prick test to 10 common environmetal airborne allergens. - Exhaled NO measurement, according to ERS/ATS recommendations. - Questionnaires to assess symptoms of asthma, co-morbidity and smoking status. | — |
Contacts
Public ContactNiki Fens
Clinical Research Fellow 'Electronic Nose' Academic Medical Center (AMC) University of Amsterdam Department of Pulmonology F5-260 P.O.Box 22660
Outcome results
None listed