Long-term memory.
Conditions
Interventions
Participants will participate on 4 separate test days and will be administered either rivastigmine, biperiden, a combination, or a placebo. The order of treatment will be counterbalanced.
Sponsors
Anke Sambeth
Eligibility
Inclusion criteria
Inclusion criteria: 1. Male or female; 2. 18 to 35 years of age; 3. healthy (i.e. absence of all exclusion criteria); 4. body mass index between 18.5 and 30; 5. willingness to sign an informed consent.
Exclusion criteria
Exclusion criteria: 1. History of cardiac, hepatic, renal, pulmonary, neurological, gastrointestinal, haematological, or psychiatric ilness; 2. excessive drinking (> 20 glasses of alcohol containing beverages a week); 3. pregnancy or lactation; 4. use of medication other than oral contraceptives; 5. use of recreational drugs from 2 weeks before the experiment until the end of the study; 6. any sensory or motor deficits which could reasonably be expected to affect test performance; 7. having a first-degree relative with a psychiatric disorder.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is the behavioral score on a set of memory paradigms, namely a verbal learning task, a picture memory task, and a spatial memory task. Furthermore, the brain activity (EEG and event-related potentials) will be recorded during those tasks. | — |
Secondary
| Measure | Time frame |
|---|---|
| The behavioral response and brain activity during a choice reaction time task is recorded in order to find out whether the medication also has sedative effects. | — |
Contacts
Public ContactAnke Sambeth
Faculty of Psychology Dept. of Neuropsychology and Psychopharmacology PO Box 616
Outcome results
None listed