Unexplained subfertility, scratching, live birth, implantation, endometrium
Conditions
Interventions
The scratch will be performed in a natural cycle with LH testing. The scratch will be performed 6 to 7 days after the positive LH test. If, for the individual patient, scheduling on this day is imposs
Sponsors
UMC Utrecht
Trial executed within the NVOG-consortium 2.0
Eligibility
Inclusion criteria
Inclusion criteria: 1. Diagnosis of Unexplained Infertility (UEI) and a Hunault of > 30%. 2. Female age 18-43 years 3. Primary or secondary infertility lasting at least 1 year 4. Regular menstrual cycle 5. Patent tubes (diagnosed by negative Chlamydia antibody titre and absence of risk factors for tubal disease, and/or hysterosalpingography or diagnostic laparoscopy) 6. Total motile sperm count > 3 million/ml 7. Normal transvaginal ultrasound, defined as no visible intracavitary pathology or intramural myomas with impression of the uterine cavity 8. Written informed consent
Exclusion criteria
Exclusion criteria: 1. History of lower abdominal or pelvic infection 2. Higher chance of intra-abdominal infection due to intestinal surgery (for for instance Crohn’s disease or colitis) 3. Endometriosis grade 3 and 4 4. Previous caesarean section with niche formation 5. The presence of untreated unilateral or bilateral hydrosalpinx 6. Recurrent miscarriage (defined as 2 or more pregnancy losses prior to 20 weeks of gestation) 7. Previous endometrial scratching 8. Meno-metrorrhagia (defined as any intermenstrual loss of blood) 9. Untreated/unsubstituted endocrine abnormalities (e.g. pituitary, thyroid, adrenal or pancreas)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cumulative live birth rate (of which the ‘ongoing’ status should be achieved within 12 months after randomisation) | — |
Secondary
| Measure | Time frame |
|---|---|
| - Ongoing pregnancy rate - Clinical pregnancy rate - Miscarriage rate - Twin birth rate - Time to pregnancy - Progression to IUI treatment - Progression to IVF treatment - Costs - Endometrial tissue parameters in relation to reproductive succes or failure | — |
Contacts
Public ContactHelen Torrance
Heidelberglaan 100
Outcome results
None listed