None listed
Conditions
Interventions
None listed
Sponsors
Academic Medical Centre, Amsterdam
Eligibility
Inclusion criteria
Inclusion criteria: 1. Previous (serrated) adenoma(s) on colonoscopy; 2. Previous colon carcinoma for which partial colectomy was performed; 3. Hereditary non-polyposis colorectal cancer (either genetically proven by a mutation in one of the mismatch repair genes or with a clinical diagnosis according to the Amsterdam II criteria); 4. Positive family history for CRC; 5. Known present (serrated) adenoma(s) or colorectal cancer.
Exclusion criteria
Exclusion criteria: 1. Pregnancy; 2. Beta-blocker use; 3. Non-correctable coagulopathy precluding biopsies; 4. Age under 18 years; 5. Inability to give informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. The feasibility of confocal endomicroscopy; represented by: A. The sensitivity and specificity of optical biopsies (using final histopathology as gold standard). The sensitivity and specificity will be calculated for both the real time endoscopy diagnosis and the blinded assessment afterwards; B. In addition, the percentage of confocal images with insufficient image quality for histopathological diagnosis will be calculated on a per lesion basis. | — |
Secondary
| Measure | Time frame |
|---|---|
| The accuracies of CE, NBI, AFI and confocal endomicroscopy for the endoscopic differentiation of detected lesions will be compared with final histopathology as gold standard. | — |
Contacts
Public ContactT. Kuiper
Meibergdreef 9
Outcome results
None listed