Coronary bypass, chronic pain, duloxetine, pregabalin, placebo
Conditions
Interventions
Two weeks before elective surgery patients will be treated with duloxetine 60mg, pregabalin 150mg or a placebo.
The influence of these treatments on the endogenous pain control will be evaluated
Sponsors
Leiden University Medical Center (LUMC)
Eligibility
Inclusion criteria
Inclusion criteria: Patients of either sex with American Society of Anesthesiologists score 1, 2 or 3, aged 18 to 70 years planned to undergo elective surgery involving a sternotomy may be enrolled in the study.
Exclusion criteria
Exclusion criteria: 1. Pain scores > 3 (on a 11-point numerical rating scale, NRS) reported for most of the day during the past month (including angina); 2. The presence of any chronic pain disorder; 3. Regular use of analgesics for any purpose, including SNRIs, gabapentinoids, COX inhibitors or NSAIDs during the previous month; 4. Use of MAO-inhibitors within the last 14 days; 5. The presence of narrow-angle glaucoma; 6. Inability to perform psychophysical testing (e.g. in case of cognitive or psychiatric disorders); 7. Patients suffering from cognitive dysfunction; 8. Patients currently treated for depression, or any other mood disorder; 9. Inability to give informed consent; 10. Inability to communicate with the investigators; 11. Known allergies to the study medication: 12. Uncontrolled hypertension (diastolic blood pressure > 100 mmHg).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Pain on visual analogue scale (VAS) - Conditioned pain modulation (CPM) - STAI (State-Trait Anxiety Inventory) - PCS (Pain Catastrophizing Scale) - The Big Five Inventory (BFI) - Hospital Anxiety and Depression Score (HADS) | — |
Secondary
| Measure | Time frame |
|---|---|
| Chronic pain development | — |
Contacts
Public ContactAlbert Dahan
Leiden University Medical Center (LUMC), Department of Anesthesiology, P.O. Box 9600
Outcome results
None listed