Cervical cancer Lymph nodes HPV Cervixcarcinoom Lymfeklieren HPV
Conditions
Interventions
- patients will be asked to give permission to search for sentinel node(s), by injecting patent blue
- patients will be asked to donate 2x 10 ml blood for further analysis (at two different timepoint
Sponsors
NKI-AVL
Eligibility
Inclusion criteria
Inclusion criteria: - Age ≥ 18 years at start of the study; - Primary carcinoma of the cervix; - Operation at the NKI-AVL or AMC/VUmc; - Signed informed consent.
Exclusion criteria
Exclusion criteria: - Patients with cervical cancer other than squamous, adeno- or adenosquamous origin.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To analyse the microenvironment of (S)LNs and PT (i.e. antigen presenting cells and other immune cells) and other immune factors produced by the tumour cells in patients with cervical cancer. | — |
Secondary
| Measure | Time frame |
|---|---|
| - to assess the difference of the microenvironment of tumour-negative and metastatic LNs - to assess the difference of the microenvironment of SLNs and nonSLNs - to analyse the difference in the (S)LNs compared to the primary tumour - to assess the effect of the cervical tumour on the systemic immunity | — |
Contacts
Public ContactJossie Rotman
VUmc-Cancer Center Amsterdam, CCA 2 - 48
Outcome results
None listed