Healthy volunteers
Conditions
Interventions
Placebo and 15 mcg LSD
Sponsors
Maastricht University Department of Psychology and Neurosciences
Eligibility
Inclusion criteria
Inclusion criteria: • Having had at least one full-psychedelic experience (regular dose) with LSD, psilocybin, ayahuasca, DMT, Salvinorin, Mescaline, MDMA, NBOMe, 2Cs or any other psychedelic drug, but not within the past 3 months. • Proficient knowledge of the English language • Written Informed Consent • Understanding the procedures and the risks associated with the study. • Age between 18 and 65 years • Absence of any major medical condition as determined by medical examination and laboratory analysis • Absence of any major psychological condition as determined by medical examination • Free from psychotropic medication • Participants must be willing to refrain from taking illicit psychoactive substances during the study. • Participants must be willing to drink only alcohol-free liquids and no coffee, black or green tea, or energy drink after midnight of the evening before the study session, as well as during the study day. • Participants must be willing not to drive a traffic vehicle or to operate machines within 24 h after substance administration. • Normal weight, body mass index (weight/height2) between 18 and 28 kg/m2
Exclusion criteria
Exclusion criteria: • History of drug addiction (determined by the medical questionnaire, drug questionnaire and medical examination) • Previous experience of serious side effects to psychedelic drugs (anxiety or panic attacks) • Pregnancy or lactation • Hypertension (diastolic > 90 mmHg; systolic > 160 mmHg) • Current or history of psychiatric disorder (determined by the medical questionnaire and medical examination) • Psychotic disorder in first-degree relatives • Any chronic or acute medical condition • History of cardiac dysfunctions (arrhythmia, ischemic heart disease,…) • For women: no use of a reliable contraceptive • Tobacco smoking (>20 per day) • Excessive drinking (>20 alcoholic consumptions per week) • Prior exposure to False Memories paradigm
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary objective is to examine the possible positive mood and positive subjective effects following repeated doses of 15 mcg LSD compared to placebo. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary objective is to examine the possible induced cognitive performance and increase in neuroplasticity following repeated doses of 15 mcg LSD compared to placebo. | — |
Contacts
Public ContactNadia Hutten
Maastricht University
Outcome results
None listed