urticartia, urticaria factitia, dermographic urticaria, netelroos
Conditions
Interventions
- histamine prick test
- dermography test
15 UF patients are compared with 15 healthy controls regarding MEG changes using network theory measures. These measures will be compared between the two gr
Sponsors
VUmc
Eligibility
Inclusion criteria
Inclusion criteria: General inclusion criteria In order to be eligible to participate in this study, a subject must meet all of the following criteria: - 18 years or older - Informed consent given Inclusion criteria for UF patients In order to be eligible to participate in this study, a UF patient must meet all of the following criteria: - UF diagnosed by a dermatologist - UF in active phase, i.e., wheals arise when antihistaminic drugs are stopped
Exclusion criteria
Exclusion criteria: General exclusion criteria A potential subject who meets any of the following criteria will be excluded from participation in this study: - Participants that cannot read, speak or understand Dutch - Mentally incompetent individuals who are not capable to provide informed consent, as determined by their treating physician - Conditions that will cause excessive MEG artefacts (cardiac pacemaker/cardiac or neural defibrillators, metal fragments in the eyes, metal plates, piercings, pins or bolts in head, any magnetic implantation/implantations made from iron (ferrous products, including braces and splints) - Systemic medication: corticosteroids, ciclosporine, montelukast, hydroxychloroquine, dapson, omalizumab, methotrexate - The antihistaminic drug should be stopped 4 days in advance Exclusion criteria for healthy controls - Participants with a history of any form of urticaria - Participants who use antihistaminic drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Difference in local and global connectivity between UF patients and healthy controls during the baseline measurement - Difference in local and global connectivity between UF patients and healthy controls after a histamine prick test - Difference in local and global connectivity between UF patients and healthy controls after dermography | — |
Secondary
| Measure | Time frame |
|---|---|
| - Differences in the itch score (VAS) before and after a histamine prick test and dermography, DASS and serum levels of stress related mediators (CRH, ACTH, prolactine, cortisol, NGF, BDNF, SP) between UF patients and the control group. - Correlation between ‘global connectivity’ after a histamine prick test and the itch score (VAS), area of a histamine prick test wheal and flare, UCT, CU-Q2oL, DASS and serum levels of stress mediators (CRH, ACTH, prolactine, cortisol, NGF, BDNF, SP). - Correlation between ‘global connectivity’ after dermography and the itch score (VAS), width of the dermography wheal, UCT, CU-Q2oL, DASS and serum levels of stress mediators (CRH, ACTH, prolactine, cortisol, NGF, BDNF, SP) In case of detectable regional differences in connectivity measures after a histamine prick test or dermography between UF patients and the control group: - Correlation between ‘local connectivity’ after a histamine prick test and the itch score (VAS), area of a histamine prick test wheal and flare, UCT, CU-Q2oL, DASS and serum levels of stress mediators (CRH, ACTH, prolactine, cortisol, NGF, BDNF, SP). - Correlation between ‘local connectivity’ after dermography and the itch score (VAS), width of the dermography wheal, UCT, CU-Q2oL, DASS and serum levels of stress mediators (CRH, ACTH, prolactine, cortisol, NGF, BDNF, SP). | — |
Contacts
Public ContactM. Frölich
Outcome results
None listed