Folic acid and carotid intima-media thickness: a 3-year RCT examining the effects of folic acid supplementation on vascular disease.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON21998

Enrollment

819

Registered

2005-01-21

Start date

1999-09-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

3-year long daily (oral) supplementation with 0.8 mg folic acid vs. placebo pill.

Eligibility

Inclusion criteria

Inclusion criteria: 1. 50-70 years old; 2. Men and post-menopuasal women; 3. Vitamin B12 >=200 pmol/L; 4. Homocysteine >=13 umol/L.

Exclusion criteria

Exclusion criteria: 1. No current use of vitamin supplements containing B vitamins; 2. No hormone replacement therapy or lipid-lowering therapy.

Design outcomes

Primary

Measure	Time frame
Progression in intima-media thickening of the common carotid artery, progression in carotid arterial stiffening, decline in cognitive performance using a battery of test, decline in hearing threshold levels.	—

Contacts

Public ContactJane Durga

Wageningen University, Division of Human Nutrition, P.O. Box 8129

Jane.Durga@wur.nl+31 (0)317 485443

Outcome results