Healthy volunteers, Food allergy, exercise, intestinal permeability, gezonde vrijwilligers, voedselallergie, inspanning, darmdoorlaatbaarheid
Conditions
Interventions
Intake of 100grams of roasted peanuts during 2 test days
Intake of 5g Lactulose and 1gr L-rhamnose during two test days
Blood sampling via venflon cannula at baseline and 30, 60, 90, 120, and 240 min
Sponsors
Wageningen University
Eligibility
Inclusion criteria
Inclusion criteria: - 20-35 year old males and females - Body mass index (BMI) 23-27.5 kg/m2 - Suitable veins for blood sampling - No inhibitory matrix effect in Ara h6 ELISA method - Able to cycle 1h on ergometer
Exclusion criteria
Exclusion criteria: - History of peanut allergy - Known symptoms of immune disease, such as diabetes, gastritis, and coeliac disease. - Pregnant or lactating - Known symptoms of intestinal disease, such as Crohn’s Disease, ulcerative colitis, and irritable bowel syndrome. - Smoking - Use of hard drugs - Use of specific medicines: o Chronic use of NSAIDs: aspirins, ibuprofen, etc. o Drugs having an effect on gastric and/or intestinal function and motility, including antidepressants. - Participation in other scientific studies - Blood donation during the last six weeks before the start and during the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the difference in serum Ara h6 levels over time between a resting and an exercise condition | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary endpoint is the level of exercise-induced permeability Other outcomes: Body weight, height, intestinal integrity-related markers, such as I-FABP | — |
Contacts
Public ContactLonneke Janssen Duijghuijsen
Wageningen UR Food and Biobased Research
Outcome results
None listed