obesity, insulin resistance, metabolic syndrome, obesitas, insulineresistentie, metabool syndroom
Conditions
Interventions
None listed
Sponsors
Academic Medical Center
Eligibility
Inclusion criteria
Inclusion criteria: 1. Scheduled for malabsorptive bariatric surgery; 2. Age 18-65 years; 3. Stable weight for 3 months prior to inclusion.
Exclusion criteria
Exclusion criteria: 1. Major bleeding disorder; 2. Renal insufficiency (creatinine > 150 umol/L), liver enzymes > 3x ULN; 3. All medical conditions except for obesity related diseases and thyroid disorders; 4. Unable to read or speak the Dutch language.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. To identify predictive variables correlated with percentage excess weight loss (EWL), reversal of metabolic complications of obesity, quality of life after bariatric surgery and postoperative complications (special focus on inflammatory pathways and eating behavior); 2. To identify metabolic variables (using a metabolomics approach) in plasma and tissue (adipose tissue as well as liver) correlated with metabolic health c.q. markers of the metabolic syndrome. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To assess the prevalence of hypertension and metabolic complications of obesity in obese patients scheduled for bariatric surgery; 2. To study the association of eating behavior with possible polymorphisms involved in appetite regulation and with markers of metabolic health. | — |
Contacts
Public ContactMurat Kilicarslan
Outcome results
None listed