Obsessive-compulsive disorder
Conditions
Interventions
Deep brain stimulation of the ventral anterior limb of the internal capsule
Sponsors
Board of Directors, Academic Medical Center, Amsterdam
Eligibility
Inclusion criteria
Inclusion criteria: Subject has provided informed consent. Primary diagnosis of OCD with DBS-implantation performed in the AMC in the previous years. Primary diagnosis of OCD and indicated for DBS-implantation in the AMC. DBS-treatment responsiveness, defined as an improvement in Y-BOCS of >35% at last follow-up compared to pre-surgical baseline.
Exclusion criteria
Exclusion criteria: Subject is unwilling or unable to comply with all study-required follow-up evaluations. Alcohol or substance abuse during last 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. DBS-related changes in amplitude, phase stability and cortocostriatal connectivity of theta (~4 Hz), alpha (~10 Hz) and gamma (>40 Hz) EEG oscillations at electrode contacts and scalp 2. Amplitude, phase stability of theta, alpha and gamma EEG oscillations measured at the electrodes that prelude and accompany the emergence of a compulsive episode during real-life situations and in experimental settings 3. DBS-related clinical changes on clinician-rated questionnaires: - Yale Brown of Obsessive-Compulsive Scale (Goodman et al., 1989) - Hamilton Scale for Depression (Hamilton, 1960) - Hamilton Anxiety Scale (Hamilton, 1959) - Symptom provocation during IAPS picture task (Bradley | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Characterictics of corticostriatal EEG oscillations that are associated with various cognitive and behavioral paradigms and with sleep. 2. Written diary of OCD symptom experiences and daily activities 3. Demographic information not obtainable for clinical file (e.g. handedness) | — |
Contacts
Public ContactMelisse Bais
Academisch Medisch Centrum, Amsterdam
Outcome results
None listed