Pharmacometrics Prediction Sepsis Infectious disease Personalized medicine Antibiotics Antibiotica Farmacometrie Infectieziekten Predictiemodellen
Conditions
Interventions
For the prospective part of the study we will take an average of six blood samples per patient, per antibiotic/antimycotic.
Sponsors
VU University Medical Center
Eligibility
Inclusion criteria
Inclusion criteria: For the prospective part of this study, the inclusion criteria are: In order to be eligible to participate in this study, a subject must meet all of the following criteria: - Age ≥ 18 years - The patient is receiving antibiotics and/or antimycotic agents to treat an infectious disease. For the retrospective part of this study the inclusion criteria are: - The patient has been treated on the Intensive Care unit of the VUmc or OLVG Oost and the patient data has been stored in an electronic patient file (in OLVG from 1999 and VUmc from 2003) - There is at least 1 relevant pharmacometric outcome measure available (e.g. vancomycine plasma concentration)
Exclusion criteria
Exclusion criteria: none
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| • Agreement between predicted and observed relevant pharmacometric parameters using Bland-Altman analysis • Percentage of correct first predictions of each pharmacometric model. • Extent to which all relevant pharmacometric goals are being met. | — |
Contacts
Public ContactB. van Dijk
Outcome results
None listed