L-AGE studie

The effect on embryo-quality of rLH-addition to rFSH for controlled ovarian hyperstimulation in women with poor ovarian reserve

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON21944

Enrollment

220

Registered

2008-09-24

Start date

2008-09-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

LH, embryo quality, IVF, live birth rate

Interventions

1. 300 rFSH sc daily alone or 2. 2:1 ratio rFSH : rLH i.e. 300 IU/L rFSH and 150 IU/L rLH sc

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients between 35 and 43 years of age 2. Patients with IOF, <35 years 3. Valid indication for IVF or ICSI 4. Undergoing IVF/ICSI first oocyte retrieval

Exclusion criteria

Exclusion criteria: Endocrinopathological disease as: Cushing’s syndrome, adrenal hyperplasia, hyperprolactinaemia, acromegaly, hypothalamic amenorrhea, hypothyroidy, diabetes mellitus type I, PCOS If not willing or able to sign the informed consent form

Design outcomes

Primary

Measure	Time frame
Percentage of top-quality embryos	—

Secondary

Measure	Time frame
- Number of follicles > 14 mm on hCG day - Number of retrieved oocytes - Number of metaphase II oocytes - Pronuclear morphology - Total number of embryos - Presence of early cleavage - Cleavage stage morphology - Number of embryos suitable for transfer - Biochemical, clinical, ongoing pregnancies - Live-birth rate	—

Contacts

Public ContactA.M. Musters

Academisch Medisch Centrum Afdeling Gynaecologie en Verloskunde

a.m.musters@amc.nl+31 (0)20 5669111 (sein: 59426)

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)