National immunization program (NIP), preterm infants, immune response
Conditions
Interventions
No interventions. This is an observational study on immune respons after vaccination in preterm infants according to the current NIP schedule.
Sponsors
Rijksinstituut voor Volksgezondheid en Milieu (RIVM)
Antonie van Leeuwenhoeklaan 9
3721 BM Bilthoven
030 - 274 91 11
info@rivm.nl
Postadres:
Postbus 1
3720 BA Bilthoven
Eligibility
Inclusion criteria
Inclusion criteria: - Eligible for RIVAR study (This study is nested within an observational step-wedged cohort non-WMO study,RIVAR) - Preterm infant (36 weeks of gestational age or younger).-
Exclusion criteria
Exclusion criteria: Not willing to take part in blood sampling
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Seroconversion rates at 5 and 12 months of age in preterm infants and absolute antibody levels against the regular NIP vaccine components (DTaP, IPV, HIb, HepB and PCV10. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Levels of maternal antibodies at 6 weeks of age - Parameters of cellular immunity at 12 months - Timelines of NIP vaccines - Tolerability and vaccine side effects - Rotavirus seroconversion rates and antibody levels at 5 an 12 months of age among those vaccinated and not-vaccinated against rotavirus. | — |
Contacts
Public ContactLydeke Zwart
Research Support Unit Julius Centrum - UMC Utrecht
Outcome results
None listed