Antibiotics/ Antibiotica Infection/ Infectie Procalcitonin/ Procalcitonine Biomarker/ Biomarker
Conditions
Interventions
When procalcitonin has reached a peaklevel of above 1,0 ng/ml and the value has decreased to below 0,25 ng/ml, there will be adviced to stop antibiotics (absolute decrease).
A second intervention ru
Sponsors
None listed
Eligibility
Inclusion criteria
Inclusion criteria: Any patient over the age of 18, admitted to the ICU and receiving antibiotics for an assumed infection can be enrolled into this trial. Informed consent has to be obtained in writing from the patient of his/her relatives prior to inclusion.
Exclusion criteria
Exclusion criteria: 1. Failure to obtain written consent to participate; 2. Patients receiving prolonged antibiotic therapies (> 3 weeks, e.g. endocarditis); 3. Patients with severe infections due to viruses or parasites; 4. Patients entering the ICU for post-operative observation and/or on antibiotic prophylaxis with an estimated length of stay less then 24 hrs; 5. Patients suffering from plasmodium falciparum malaria, active tuberculosis or cystic fibrosis; 6. Neutropenic patients; 7. Moribund patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Consumption of antibiotics expressed as the Defined Daily Dosage and duration of antibiotic therapy expressed in days of therapy. In case of multiple antibiotic therapies the therapy that will be used the longest will be scored in duration of therapy; 2. 28-day mortality. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The percentage of new episodes of bacterial infections for which antibiotics are prescribed per 1.000 ICU days; 2. Length of ICU stay, measured after discharge from the ICU in days; 3. Acquisition costs of antibiotics (in Euro’s); 4. Costs of procalcitonin (in Euro’s). | — |
Contacts
Public ContactE. Jong, de
room 4A51 Boelelaan 1117,
Outcome results
None listed