hepato-pancreato-biliary cancer, HPB, fatigue, quality of life, muscle mass, rehabilitation.
Conditions
Interventions
Physical therapy: Every week 2x 2hr for 12 weeks,
At home Solution Focused Therapy: Every other week 1x 1hr for 12 weeks.
Diatary support: if at risk for malnutrition
Sponsors
Erasmus MC
Eligibility
Inclusion criteria
Inclusion criteria: • Undergoing curative intent surgery for HPB malignancies. Liver surgery will be defined as major if a left or right (extended) hemihepatectomy or if 3 or more segments are resected and minor if less than 3 segments are resected. • Clinically suspect or histologically confirmed liver, bile duct or pancreatic carcinoma; • Life expectancy of at least six (6) months; • Fatigue score ≥ 4 on a numeric rating scale (NRS) with scores of 0 to 10 • Able to read and understand the Dutch language; • Written informed consent.
Exclusion criteria
Exclusion criteria: • Treatment with adjuvant chemo(radiation)therapy • Bone metastases or other high risk of fractures; • Not able to perform basic activities of daily living (ECOG ≥3); • Decompensated heart disease, uncontrolled hypertension (systolic blood pressure > 200 mmHg or diastolic blood pressure > 110 mmHg), heart failure (NYHA Class II or greater) or chronic obstructive pulmonary disease causing fatigue; • Living in nursing homes; • Cognitive impairment; • BMI 5% weight loss per month or other health problems that would not allow physical exercise training; • Anxiety or depression requiring psychiatric consultation; • Cancer treatment in the previous 5 years (except basal skin cancer); • Participation in other studies containing elements of physical exercise or psychological therapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MFI-20 General Fatigue at 12 months after surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| MFI-20, Quality of life, Frailty, Anxiety and Depression, physical status, activity level, survival, cost-utility | — |
Contacts
Public ContactB. Beumer
Outcome results
None listed