Colorectal carcinoma
Conditions
Interventions
1. Patient triage medical conditions
2. Exercise program
3. Nutritional supplements
4. Smoke cessation
5. Psychological coping
Sponsors
Máxima MC
Eligibility
Inclusion criteria
Inclusion criteria: Adult patients undergoing elective colorectal surgery for cancer.
Exclusion criteria
Exclusion criteria: • metastatic disease known preoperatively, • paralytic or immobilized patients (not capable to perform exercise or 6MWT), • premorbid conditions or orthopedic impairments that contraindicate exercise (to be assessed by sport physician involved in and during cardiopulmonary exercise testing), • cognitive disabilities, • chronic renal failure (dialysis or creatinine > 250 µmol)m • ASA score 4 or higher, • illiteracy (disability to read and understand Dutch), • planned abdominoperineal resection (inability to perform postoperative tests), • second primary tumour other than colorectal carcinoma simultaneously diagnosed, • not able to delay surgery for four weeks due to for example clinical signs of obstruction or short-course neoadjuvant radiotherapy, directly followed by surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The first primary outcome is postoperative complications, as scored using the Comprehensive Complication Index score as a combined outcome measure of morbidity and mortality. The second primary/confirmatory outcome is the patients’ functional capacity, as measured by the six-minute walk test (6MWT). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes will include indirect 1 repetition measures (1-RM) and cardiopulmonary exercise testing (CPET), Health-related quality of life (HRQL), Sit-to-Stand test, Fried Frailty Score, hand grip strength, body composition, stair climb test, Physical activity level measured through an activity questionnaire, depression and anxiety assessed by GAD-7 and PHQ-9, nutritional status, compliance, length of hospital stay, and costs. | — |
Contacts
Public ContactGerrit Slooter
P.O. Box 7777
Outcome results
None listed