Thrombin Generation after Abrupt Cessation versus Weaning over 8 hours of Continuous Infusion of Unfractionated Heparin in ICU-patients after Discontinuation of Continuous Venovenous Hemofiltration.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON21886

Enrollment

Registered

2006-08-02

Start date

2006-09-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aburpt cessation of continuous intravenous treatment with Unfractionated Heparin.

Interventions

Therapeutic protocol: Prophylactic LMWH will not be given within 24 hours of discontinuation of CVVH. Patients are treated with help of standard guidelines effective in our units. The full medical tr

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients scheduled to stop treatment with CVVH because they no longer require it (physicians discretion/local protocol); 2. Age >18 years; 3. At least 48 hours of CVVH treatment with concomitant continuous infusion of UFH; 4. At least 36 hours of continuous UFH infusion in the last 48 hours prior to inclusion.

Exclusion criteria

Exclusion criteria: 1. Patients with known coagulation disorders; 2. Patients receiving any anti-coagulant treatment for reasons other than CVVH.

Design outcomes

Primary

Measure	Time frame
Thrombin-Antithrombin complexes (TATc).	—

Secondary

Measure	Time frame
aPTT, anti-Xa, factor VII/VIIa, TF, TFPI-antigen, TFPI activity, protein C / activated protein C, aPC-sr, prothrombine fragment 1.2, ETP (Endogenous Thrombin Potential), Fibrin monomers, soluble thrombomodulin, PAPc, PAI.	—

Contacts

Public ContactJ.J. Hofstra

Academic Medical Center (AMC) IC Unit, P.O. Box 22660

J.J.Hofstra@amc.uva.nl+31(0)20 5668224

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)