helium coronary circulation coronary vessel diameter coronary micro vascular resistance
Conditions
Interventions
During PCI, participants will breathe helium 79% during 10 minutes. Measurements will be done both before and after helium inhalation.
Sponsors
Academic Medical Center, University of Amsterdam
Eligibility
Inclusion criteria
Inclusion criteria: 1. Elective Percutaneous coronary intervention (PCI) of the left anterior descending artery (LAD); 2. Age >18 years; 3. Written informed consent.
Exclusion criteria
Exclusion criteria: 1. Acute coronary syndrome; 2. Cardiogenic shock; 3. Prior coronary artery bypass grafting (CABG); 4. Presence of a significant left main coronary artery stenosis (> 50% diameter stenosis); 5. Diffuse disease; 6. Diabetes; 7. Severe pulmonary disease; 8. Kidney failure (clearance <30 ml/min); 9. Liver failure; 10. Prior revascularisation; 11. Consecutive stenoses in a single artery; 12. Expected inability to complete the study protocol; 13. Participation in another study using ionizing radiation within the last year; 14. Employed in a profession using ionizing radiation; 15. Use of a non-selective betablokker.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Coronary flow reserve (CFR) in the LAD. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Fractional flow reserve (FFR) in the LAD; 2. MR in the LAD; 3. Lumen diameter of the RCx; 4. Vessel diameter of the RCx; 5. CFR in the RCx; 6. FFR in the RCx; 7. MR in the RCx; 8. Collateral flow index (CFI); 9. Global hemodynamic parameters during helium application; 10. Complications during and following PCI. | — |
Contacts
Public ContactDaniel Brevoord
Postbus 22660, M0-126
Outcome results
None listed