None listed
Conditions
Interventions
Intraarticular corticosteroid injection or placebo after 72 hours of adequate antibiotic regimen for bacterial artritis.
Sponsors
Academisch Medisch Centrum, Universiteit van Amsterdam, Amsterdam
Eligibility
Inclusion criteria
Inclusion criteria: 1. Provision of a written informed consent; 2. Age range 18-85; 3. Bacterial arthritis of at least on of the following native joints: Wrist, elbow, shoulder, knee or ankle; 4. Positive culture of synovial fluid.
Exclusion criteria
Exclusion criteria: 1. Adequate antibiotic therapy > 72 hours at time of inclusion; 2. Overt signs of osteomyelitis on conventional X-rays; 3. Bacterial arthritis of a prosthetic joint; 4. Surgical drainage of the infected joint before inclusion; 5. Need for surgical drainage at time of inclusion; 6. Bacterial arthritis due to Borrelia burgdorferi or mycobacteria; 7. Allergy for corticosteroids; 8. Mental condition rendering the subject unable to understand the nature, scope and possible consequences of the study and/or evidence of an uncooperative attitude; 9. Clinical judgment by the investigator that the subject should not participate in the study, such as severe co-morbidity.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The difference of the range of Blantyre Septic Joint Score (BSJS) measurements between placebo en active treatment group at multiple corresponding time points. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Safety; 2. ESR and CRP; 3. Cartilage Oligomeric Matrix Protein (COMP); 4. Radiological joint damage; 5. Measurement of Health Status with SF-36; 6. Visual Analog Scale (VAS) measurements. | — |
Contacts
Public ContactJ.T. Dissel, van
Leids Universitair Medisch Centrum Postbus 9600
Outcome results
None listed