A study on organ protection during bypass sugery by inflating a bloodpressure cuff on the arm.

A clinical study to investigate the molecular effects of remote ischemic preconditioning in the myocardium of CABG patients.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON21859

Enrollment

Registered

2009-07-27

Start date

2009-07-28

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

CABG, remote preconditioning, cardioprotection

Interventions

Remote ischemic preconditioning: By inflating a automateic inflator cuff around the upper arm, we will induce forearm ischemia for 5 minutes, followed by 5 minutes of reperfusion. This cylce will be r

Eligibility

Inclusion criteria

Inclusion criteria: 1. CABG surgery with or without valve surgery; 2. Informed consent; 3. Age >18 years.

Exclusion criteria

Exclusion criteria: 1. Emergency surgery; 2. Heart failure; 3. Serious pulmonary disease; 4. Kidney failure.

Design outcomes

Primary

Measure	Time frame
Differences in phosphorylation of PKC-e, p38MAKP, ERK and HSP27, before and after remote preconditioing, as compared to control.	—

Contacts

Public ContactB. Preckel

Department of Anesthesiology, Academic Medical Center University of Amsterdam, Meibergdreef 9 Postbus 22660 H1Z-120

b.preckel@amc.uva.nl+31 20 5662162,

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)