Imaging-based evaluation of the treatment of tremor by targeted lesioning of the brain

Evaluation of the cerebello-rubro-thalamic tract after (sub)thalamotomy

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON21836

Enrollment

Registered

2016-01-28

Start date

2016-02-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thalamotomy

Interventions

- Tremor registration and video registration, followed by a clinical tremor rating scale assessment - Short questionnaire about patient satisfaction - Repeat MRI with diffusion weighted imaging

Eligibility

Inclusion criteria

Inclusion criteria: - Adult patients (>18 years old) - Treatment for tremor with (sub)thalamotomy in the UMCG - Written informed consent

Exclusion criteria

Exclusion criteria: - Contra-indications to MRI examination (e.g. heart pacemaker, metal foreign body in eye, aneurysm clip in brain, severe claustrophobia) - Implantation of DBS electrodes - Patients with a life expectancy less than 6 months - Patients physically not able to lie flat for one hour

Design outcomes

Primary

Measure	Time frame
In all patients: relation between tremor severity and localization of the lesion. Relation between clinical tremor severity and radiographic (DTI) features of the cerebello-rubro-thalamic tract. - The difference in localization of the lesioned area in the brain towards the preoperative assessed target measured in millimetres - The volume of the cerebello-rubro-thalamic tract involved in the lesioned area and compared to the contralateral side - Tremor severity as measured by accelerometers (amplitude and frequency) and the Bain & Findley Clinical Tremor Rating Scale	—

Measure

Time frame

In all patients: relation between tremor severity and localization of the lesion. Relation between clinical tremor severity and radiographic (DTI) features of the cerebello-rubro-thalamic tract. - The difference in localization of the lesioned area in the brain towards the preoperative assessed target measured in millimetres - The volume of the cerebello-rubro-thalamic tract involved in the lesioned area and compared to the contralateral side - Tremor severity as measured by accelerometers (amplitude and frequency) and the Bain & Findley Clinical Tremor Rating Scale

—

Secondary

Measure	Time frame
Patient satisfaction after (sub)thalamotomy using a short questionnaire (VAS score).	—

Contacts

Public ContactD.L.M. Oterdoom

UMCG

d.l.m.oterdoom@umcg.nl

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)