Parkinson's disease, Deep Brain Stimulation, Parkinson's disease dementia (PDD)
Conditions
Interventions
No intervention is formally tested. Patients eligible for STN-DBS after routine screening in the DBS centres will be operated on according to standard procedures. Questionnaires and rating scales will
Sponsors
Leiden University Medical Center, dept. of Neurology
Eligibility
Inclusion criteria
Inclusion criteria: Age > 18 years Diagnosis of idiopathic Parkinson's disease Clinical indication for STN-DBS at the participating centres Ability to give informed consent Ability to comply with the study assessments Ability to read or understand Dutch
Exclusion criteria
Exclusion criteria: Exclusion criteria (contra-indications) for STN-DBS: Parkinson's disease severity: HY stage 5 Score on Mattis Dementia Rating scale <120 Psychiatric contraindications for STN-DBS General contra-indications for stereotactic surgery and/or general anaesthesia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Success to STN DBS is quantified as the difference in MDS-UPDRS motor scores measured during an acute stimulation challenge | — |
Secondary
| Measure | Time frame |
|---|---|
| Psychotic symptoms in the 72 hours following surgery, measured by DOS Global satisfaction with surgery scale SENS-PD composite score MDS-UPDRS motor score Cognitive decline 12 months after surgery | — |
Contacts
Public ContactM.F. Contarino
Leiden University Medical Center, Dept. of Neurology K5Q-103
Outcome results
None listed